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Article

ABCC8 Single Nucleotide Polymorphisms are Associated with Cerebral Edema in Severe TBI.

Neurocritical care - 1 Apr 2017

Jha Ruchira M, Puccio Ava M, Okonkwo David O, Zusman Benjamin E, Park Seo-Young, Wallisch Jessica, Empey Philip E, Shutter Lori A, Clark Robert S B, Kochanek Patrick M, Conley Yvette P

Abstract excerpt

OBJECTIVE: Cerebral edema (CE) in traumatic brain injury (TBI) is the consequence of multiple underlying mechanisms and is associated with unfavorable outcomes. Genetic variability in these pathways likely explains some of the clinical heterogeneity observed in edema development. A role for sulfonylurea receptor-1 (Sur1) in CE is supported. However, there are no prior studies examining the effect of genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27677908
DOI: 10.1007/s12028-016-0309-z
PMCID: PMC5550833

Genes

ABCC8

Provenance

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