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Article

Genetic Variants Associated With Intraparenchymal Hemorrhage Progression After Traumatic Brain Injury.

JAMA network open - 1 Jul 2021

Jha Ruchira M, Zusman Benjamin E, Puccio Ava M, Okonkwo David O, Pease Matthew, Desai Shashvat M, Leach Matthew, Conley Yvette P, Kochanek Patrick M

Abstract excerpt

Importance: Intracerebral hemorrhage progression is associated with unfavorable outcome after traumatic brain injury (TBI). No effective treatments are currently available. This secondary injury process reflects an extreme form of vasogenic edema and blood-brain barrier breakdown. The sulfonylurea receptor 1-transient receptor potential melastatin 4 (SUR1-TRPM4) cation channel is a key underlying mechanism. A...

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Identifiers

PMID: 34309670
DOI: 10.1001/jamanetworkopen.2021.16839
PMCID: PMC8314141

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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