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Article

Polygenic Vulnerability to Intracranial Hypertension, Hemorrhage Progression, and Outcome in Traumatic Brain Injury.

Annals of neurology - 1 Feb 2026

Miller Margaux E, Zusman Benjamin E, Phuah Chia-Ling, McNally Erin, Okonkwo David O, Pease Matthew, Desai Shashvat M, Rani Anupama, Namphol Nasathapot, Kumar Aditya, Javelosa Raemier A, Eberle Adam T, Afework Semeon, Catapano Joshua, Cox Charles S, Kochanek Patrick M, Conley Yvette P, Puccio Ava M, Jha Ruchira M

Abstract excerpt

OBJECTIVE: Growing evidence underscores the importance of host-response/secondary-injury-likely influenced by genetics-in outcome variability post-traumatic brain injury (TBI). Intracranial hypertension and hemorrhage progression are critical secondary injuries in severe TBI; these are mediated by the SUR1-TRPM4 channel (a target in clinical trials). We aimed to deconstruct the complex network surrounding...

Read the complete abstract on PubMed

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Share to Brain Injuries, Traumatic
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Multifactorial Inheritance

Share to Polymorphism, Single Nucleotide

Share to TRPM Cation Channels

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Source

Identifiers

PMID: 41235589
DOI: 10.1002/ana.78064

Genes

TRPM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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