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Article

B-Cell Lymphoma 2 (Bcl-2) Gene Is Associated with Intracranial Hypertension after Severe Traumatic Brain Injury.

Journal of neurotrauma - 15 Jan 2021

Deng Hansen, Zusman Benjamin E, Nwachuku Enyinna L, Yue John K, Chang Yue-Fang, Conley Yvette P, Okonkwo David O, Puccio Ava M

Abstract excerpt

Severe traumatic brain injury (TBI) activates the apoptotic cascade in neurons and glia as part of secondary cellular injury. B-cell lymphoma 2 (Bcl-2) gene encodes a pro-survival protein to suppress programmed cell death, and variation in this gene has potential to affect intracranial pressure (ICP). Participants were recruited from a single clinical center using a prospective observational study design....

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Identifiers

PMID: 32515262
DOI: 10.1089/neu.2020.7028
PMCID: PMC8182479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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