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Article

Role of Sulfonylurea Receptor 1 and Glibenclamide in Traumatic Brain Injury: A Review of the Evidence.

International journal of molecular sciences - 9 Jan 2020

Jha Ruchira M, Bell Josh, Citerio Giuseppe, Hemphill J Claude, Kimberly W Taylor, Narayan Raj K, Sahuquillo Juan, Sheth Kevin N, Simard J Marc

Abstract excerpt

Cerebral edema and contusion expansion are major determinants of morbidity and mortality after TBI. Current treatment options are reactive, suboptimal and associated with significant side effects. First discovered in models of focal cerebral ischemia, there is increasing evidence that the sulfonylurea receptor 1 (SUR1)-Transient receptor potential melastatin 4 (TRPM4) channel plays a key role in these critical...

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Identifiers

PMID: 31936452
DOI: 10.3390/ijms21020409
PMCID: PMC7013742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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