Article
Influence of ATP-binding cassette polymorphisms on neurological outcome after traumatic brain injury.
Neurocritical care - 1 Oct 2013
Cousar J'mir L, Conley Yvette P, Willyerd F Anthony, Sarnaik Ajit A, Puccio Ava M, Empey Philip E, Kochanek Patrick M, Bell Michael J, Okonkwo David O, Clark Robert S B
Abstract excerpt
BACKGROUND: As important mediators of solute transport at the blood-brain and blood-cerebrospinal fluid barriers, ATP-binding cassette (ABC) transporters (including ABCB1, ABCC1, and ABCC2), impact the bioavailability of drugs and endogenous substrates in the brain. While several ABCB1, ABCC1, and ABCC2 single nucleotide polymorphisms (SNPs) have been identified, their impact on outcome after traumatic brain...
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