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Article

The association of SUR1 polymorphisms with acute infarct size: The MRI-GENIE study.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Jan 2025

Deng Arlinda, Xu Huichun, Gaynor Brady J, Cole John W, Giese Anne-Katrin, Schirmer Markus D, McArdle Patrick F, Mitchell Braxton D, Wu Ona, Rost Natalia S, Kittner Steven J

Abstract excerpt

BACKGROUND: The sulfonylurea receptor 1 (SUR1) is a known mediator of cerebral edema in large ischemic strokes, however, genetically induced response variability has yet to be evaluated. SUR1, encoded by the ABCC8 gene, is an ion channel regulator in ischemia-induced cerebral edema. Previous studies in severe traumatic brain injury demonstrated four tag single nucleotide polymorphisms (SNPs) of the ABCC8 gene to...

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Brain Edema
Diffusion Magnetic Resonance Imaging
Disability Evaluation
Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ischemic Stroke

Predictive Value of Tests

Sulfonylurea Receptors

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PMID: 39489406
DOI: 10.1016/j.jstrokecerebrovasdis.2024.108109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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