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Article

IMPACT OF ABCC8 AND TRPM4 GENETIC VARIATION IN CENTRAL NERVOUS SYSTEM DYSFUNCTION ASSOCIATED WITH PEDIATRIC SEPSIS.

Shock (Augusta, Ga.) - 1 Nov 2024

Kernan Kate F, Adkins Ashley, Jha Ruchira M, Kochanek Patrick M, Carcillo Joseph A, Berg Robert A, Wessel David, Pollack Murray M, Meert Kathleen, Hall Mark, Newth Christopher, Lin John C, Doctor Allan, Cornell Tim, Harrison Rick E, Zuppa Athena F, Notterman Daniel A, Aneja Rajesh K

Abstract excerpt

ABSTRACT: Background: Sepsis-associated brain injury is associated with deterioration of mental status, persistent cognitive impairment, and morbidity. The SUR1/TRPM4 channel is a nonselective cation channel that is transcriptionally upregulated in the central nervous system with injury, allowing sodium influx, depolarization, cellular swelling, and secondary injury. We hypothesized that genetic variation in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39227362
DOI: 10.1097/SHK.0000000000002457
PMCID: PMC12001876

Genes

TRPM4
ABCC8
IMPACT

Provenance

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