Article
DNMT3A mutations define a unique biological and prognostic subgroup associated with cytotoxic T cells in PTCL-NOS.
Blood - 15 Sept 2022
Herek Tyler A, Bouska Alyssa, Lone Waseem, Sharma Sunandini, Amador Catalina, Heavican Tayla B, Li Yuping, Wei Qi, Jochum Dylan, Greiner Timothy C, Smith Lynette, Pileri Stefano, Feldman Andrew L, Rosenwald Andreas, Ott German, Lim Soon Thye, Ong Choon Kiat, Song Joo, Jaffe Elaine S, Wang Gang Greg, Staudt Louis, Rimsza Lisa M, Vose Julie, d'Amore Francesco, Weisenburger Dennis D, Chan Wing C, Iqbal Javeed
Abstract excerpt
Peripheral T-cell lymphomas (PTCLs) are heterogenous T-cell neoplasms often associated with epigenetic dysregulation. We investigated de novo DNA methyltransferase 3A (DNMT3A) mutations in common PTCL entities, including angioimmunoblastic T-cell lymphoma and novel molecular subtypes identified within PTCL-not otherwise specified (PTCL-NOS) designated as PTCL-GATA3 and PTCL-TBX21. DNMT3A-mutated PTCL-TBX21 cases...
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