Article

Genome-wide methylation profiling of Peripheral T-cell lymphomas identifies TRIP13 as a critical driver of tumor proliferation and survival

2024-02-29

Abstract excerpt

<title>Abstract</title> <p>Cytosine methylation of genomic DNA contributes to the regulation of gene expression and is involved in normal development including hematopoiesis in mammals. It is catalyzed by the family of DNA methyltransferases (DNMTs) that include DNMT1, DNMT3A, and DNMT3B. Peripheral T-cell lymphomas (PTCLs) represent a diverse group of aggressive mature T-cell malignancies accounting for approxim...

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Literature Corpus work: 3ec7fc45-6e85-5056-a232-74617157312f
DOI: 10.21203/rs.3.rs-3971059/v1

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