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Article

Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes.

Hypertension (Dallas, Tex. : 1979) - 1 Jul 2013

McDonough Caitrin W, Gong Yan, Padmanabhan Sandosh, Burkley Ben, Langaee Taimour Y, Melander Olle, Pepine Carl J, Dominiczak Anna F, Cooper-Dehoff Rhonda M, Johnson Julie A

Abstract excerpt

We sought to identify novel pharmacogenetic markers associated with cardiovascular outcomes in patients with hypertension on antihypertensive therapy. We genotyped a 1:4 case:control cohort (n=1345) on the Illumina HumanCVD Beadchip from the INternational VErapamil SR-Trandolapril STudy (INVEST), where participants were randomized to a β-blocker strategy or a calcium channel blocker strategy. Genome-spanning...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23690342
DOI: 10.1161/HYPERTENSIONAHA.111.00823
PMCID: PMC3686553

Genes

SIGLEC12

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