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Circulating resistin levels and mutation burden of the RETN gene variants predict long-term mortality in a Taiwanese population.

Scientific reports - 2 Jan 2025

Hsu Lung-An, Teng Ming-Sheng, Wu Semon, Liao Mei-Siou, Chou Hsin-Hua, Ko Yu-Lin

Abstract excerpt

Human resistin is a proinflammatory cytokine involving the development and progression of cancer and cardiovascular diseases. However, prediction of long-term outcome using circulating resistin level and its genetic determinants in a population-based study remain to be explored. After genome-wide association study (GWAS), DNA methylation (DNAm) analysis and functional assays of a RETN rs370006313 variant, we...

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DNA Methylation
Genome-Wide Association Study
Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

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Identifiers

PMID: 39747951
DOI: 10.1038/s41598-024-84142-4
PMCID: PMC11695976

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Circulating resistin levels and mutation burden of the RETN gene variants predict long-term mortality in a Taiwanese population.PMID 39747951Read ↗

Epigenome-wide association study suggests that SNPs in the promoter region of RETN influence plasma resistin level via effects on DNA methylation at neighbouring sites.Semantic proximity Read ↗

Genome-wide association study of plasma resistin levels identified rs1423096 and rs10401670 as possible functional variants in the Japanese population.Semantic proximity Read ↗

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Positive association between serum resistin and smoking was strongest in homozygotes of the G-A haplotype at c.-420 C>G and c.-358 G>A in RETN promoter: the Toon Genome Study.Semantic proximity Read ↗

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Common quantitative trait locus downstream of RETN gene identified by genome-wide association study is associated with risk of type 2 diabetes mellitus in Han Chinese: a Mendelian randomization effect.Semantic proximity Read ↗

Impacts of RETN genetic polymorphism on breast cancer development in Beni-Suef females, Egypt.Semantic proximity Read ↗

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