Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

c-Rel is dispensable for the differentiation and functional maturation of M cells in the follicle-associated epithelium.

Immunobiology - 1 Feb 2017

Sehgal Anuj, Kobayashi Atsushi, Donaldson David S, Mabbott Neil A

Abstract excerpt

M cells reside within the follicle-associated epithelium (FAE) overlying the gut-associated lymphoid tissues. These unique phagocytic epithelial cells enable the mucosal immune system to sample antigens within the lumen of the intestine. The differentiation of M cells from uncommitted precursors in the FAE is dependent on the production of receptor activator of nuclear factor-κB ligand (RANKL) by subepithelial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Dendritic Cells
Share to Organ Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peyer's Patches

Share to Proto-Oncogene Proteins c-rel

Share to RANK Ligand

Share to Receptor Activator of Nuclear Factor-kappa B

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 27663963
DOI: 10.1016/j.imbio.2016.09.008
PMCID: PMC5152706

Genes

CCL20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

c-Rel is dispensable for the differentiation and functional maturation of M cells in the follicle-associated epithelium.PMID 27663963Read ↗

A Key Role for NF-<i>κ</i>B Transcription Factor c-Rel in T-Lymphocyte-Differentiation and Effector FunctionsSemantic proximity Read ↗

RANKL-RANK interaction in immune regulatory systemsSemantic proximity Read ↗

RANK is essential for osteoclast and lymph node development.Semantic proximity Read ↗

NF-kB c-Rel is dispensable for the development but is required for the cytotoxic function of NK cellsSemantic proximity Read ↗

Transient expression of M-cell phenotype by enterocyte-like cells of the follicle-associated epithelium of mouse Peyer's patches.Semantic proximity Read ↗

An alternative pathway of NF-kappaB activation results in maturation and T cell priming activity of dendritic cells overexpressing a mutated IkappaBalpha.Semantic proximity Read ↗

Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation.Semantic proximity Read ↗

Phenotypic Analysis of a Population of IgA+ Cells in the Follicle-Associated Epithelium of Mouse Peyer's Patches.Semantic proximity Read ↗

Expression of relB is required for the development of thymic medulla and dendritic cells.Semantic proximity Read ↗

Altered Marginal Zone B Cell Selection in the Absence of IκBNS.Semantic proximity Read ↗

Abnormal organogenesis of Peyer's patches in mice deficient for NF-kappaB1, NF-kappaB2, and Bcl-3.Semantic proximity Read ↗

Phenotypic and functional characterisation of follicle-associated epithelium of rectal lymphoid tissue.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.