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Article

Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2008

Steinbrecher Kris A, Harmel-Laws Eleana, Sitcheran Raquel, Baldwin Albert S

Abstract excerpt

NF-kappaB plays a central, proinflammatory role in chronic intestinal inflammation, yet recent work suggests a predominantly protective function for this transcription factor group in some cell types of the intestine. We herein describe the conditional deletion of the NF-kappaB RelA gene in murine intestinal epithelia and determine its function in homeostatic control of enterocyte proliferation/apoptosis and...

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Source

Identifiers

PMID: 18250470
DOI: 10.4049/jimmunol.180.4.2588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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