Article
Abnormal organogenesis of Peyer's patches in mice deficient for NF-kappaB1, NF-kappaB2, and Bcl-3.
Gastroenterology - 1 Jun 2002
Paxian Stephan, Merkle Heidrun, Riemann Marc, Wilda Monika, Adler Guido, Hameister Horst, Liptay Susanne, Pfeffer Klaus, Schmid Roland M
Abstract excerpt
BACKGROUND & AIMS: Nuclear factor (NF) kappaB1, NF-kappaB2, and Bcl-3 encode for proteins of the NF-kappaB/Rel/IkappaB families, known as regulators of innate and adoptive immune responses. Targeted disruption of these genes showed essential roles in lymphoid organ development and organization. METHODS: NF-kappaB1-, NF-kappaB2-, and Bcl-3-deficient mouse lines were established, and their role in organogenesis of...
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