A Key Role for NF-<i>κ</i>B Transcription Factor c-Rel in T-Lymphocyte-Differentiation and Effector Functions

Abstract excerpt

The transcription factors of the Rel/NF-κB family function as key regulators of innate and adoptive immunity. Tightly and temporally controlled activation of NF-κB-signalling pathways ensures prevention of harmful immune cell dysregulation, whereas a loss of control leads to pathological conditions such as severe inflammation, autoimmune disease, and inflammation-associated oncogenesis. Five family members have...