Article
An alternative pathway of NF-kappaB activation results in maturation and T cell priming activity of dendritic cells overexpressing a mutated IkappaBalpha.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2007
Moore Fabrice, Buonocore Sofia, Aksoy Ezra, Ouled-Haddou Najate, Goriely Stanislas, Lazarova Elena, Paulart Frédéric, Heirman Carlo, Vaeremans Elsy, Thielemans Kris, Goldman Michel, Flamand Véronique
Abstract excerpt
Maturation of dendritic cells (DC) is a critical step in the induction of T cell responses and depends on the activation of NF-kappaB transcription factors. Therefore, inhibition of NF-kappaB activation has been proposed as a strategy to maintain DC in an immature stage and to promote immune tole...
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