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Article

RANK is essential for osteoclast and lymph node development.

Genes & development - 15 Sept 1999

Dougall W C, Glaccum M, Charrier K, Rohrbach K, Brasel K, De Smedt T, Daro E, Smith J, Tometsko M E, Maliszewski C R, Armstrong A, Shen V, Bain S, Cosman D, Anderson D, Morrissey P J, Peschon J J, Schuh J

Abstract excerpt

The physiological role of the TNF receptor (TNFR) family member, RANK, was investigated by generating RANK-deficient mice. RANK(-/-) mice were characterized by profound osteopetrosis resulting from an apparent block in osteoclast differentiation. RANK expression was not required for the commitment, differentiation, and functional maturation of macrophages and dendritic cells from their myeloid precursors but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10500098
DOI: 10.1101/gad.13.18.2412
PMCID: PMC317030

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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