Article

NF-kB c-Rel is dispensable for the development but is required for the cytotoxic function of NK cells

2021-01-20

Abstract excerpt

Natural Killer (NK) cells are cytotoxic lymphocytes critical to the innate immune system. We found that germline deficiency of NF-kB c-Rel results in a marked decrease in cytotoxic function of NK cells, both in vitro and in vivo, with no significant differences in the stages of NK cell development. We found that c-Rel binds to the promoters of perforin and granzyme B, two key proteins required for NK cytotoxicity,...

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Literature Corpus work: 2af5716a-7119-555a-a1ba-5bf5f1c8fed2
DOI: 10.1101/2021.01.19.427356

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