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Article

RANKL-RANK interaction in immune regulatory systems

1 Jan 2012

Abstract excerpt

The interaction between the receptor activator of NF-κB ligand (RANKL) and its receptor RANK plays a critical role in the development and function of diverse tissues. This review summarizes the studies regarding the functions of RANKL signaling in immune regulatory systems. Previous in vitro and in vivo studies have indicated that the RANKL signal promotes the survival of dendritic cells (DCs), thereby activating...

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PMID: 23173110
DOI: 10.5312/wjo.v3.i9.142

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