Article
Comorbidities and mutations including single- and multihit TET2 mutations in relation to outcome in chronic myelomonocytic leukaemia-A population-based study.
British journal of haematology - 1 Feb 2026
Kynning Matilda Kjellander, Westerberg Ebba, Forsell Linda, Creignou Maria, Berggren Daniel Moreno, Tesi Bianca, Bernard Elsa, Papaemmanuil Elli, Nannya Yasuhito, Franco Lucia Cavelier, Valentini Davide, Lindberg Eva Hellström, Ogawa Seishi, Ejerblad Elisabeth, Ungerstedt Johanna
Abstract excerpt
To explore the relation between disease characteristics, comorbidities, mutations and overall survival (OS) in chronic myelomonocytic leukaemia (CMML), we collected data from a population-based cohort of 149 consecutive patients. TET2 mutation (TET2MT) was associated with higher haemoglobin, less leucocytosis and longer OS compared to no TET2MT (TET2WT), despite patients being significantly older. Patients with...
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