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Article

Mutation spectra induced by replication of two vicinal oxidative DNA lesions in mammalian cells.

Mutation research - 20 Jul 2000

Gentil A, Le Page F, Cadet J, Sarasin A

Abstract excerpt

Ionizing radiations often induce multiple and clustered DNA lesions at the site of DNA interaction. As a model, we have studied the toxicity and the mutagenicity of two adjacent oxidative bases as clustered DNA lesions in mammalian cells using shuttle vectors. The chosen oxidative lesions were 8-oxo-7,8-dihydroguanine, the formylamine residue resulting from the oxidation of a pyrimidine base and the tandem lesion...

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PMID: 10894890
DOI: 10.1016/s0027-5107(00)00034-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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