Article
A Common Gene Variant in Glucokinase Regulatory Protein Interacts With Glucose Metabolism on Diabetic Dyslipidemia: the Combined CODAM and Hoorn Studies.
Diabetes care - 1 Oct 2016
Simons Nynke, Dekker Jacqueline M, van Greevenbroek Marleen M J, Nijpels Giel, 't Hart Leen M, van der Kallen Carla J H, Schalkwijk Casper G, Schaper Nicolaas C, Stehouwer Coen D A, Brouwers Martijn C G J
Abstract excerpt
OBJECTIVE: Small molecules that disrupt the binding between glucokinase and glucokinase regulatory protein (GKRP) are potential new glucose-lowering targets. They stimulate hepatic glucose disposal by increasing glucokinase activity in the liver. It can, however, be anticipated that increased hepatic glucokinase activity might be accompanied by the development of hypertriglyceridemia, particularly in type 2...
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