Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents.

doi:10.1002/hep.24806

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Article

Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents.

Hepatology (Baltimore, Md.) - 1 Mar 2012

Santoro Nicola, Zhang Clarence K, Zhao Hongyu, Pakstis Andrew J, Kim Grace, Kursawe Romy, Dykas Daniel J, Bale Allen E, Giannini Cosimo, Pierpont Bridget, Shaw Melissa M, Groop Leif, Caprio Sonia

Abstract excerpt

UNLABELLED: Recently, the single nucleotide polymorphism (SNP) identified as rs1260326, in the glucokinase regulatory protein (GCKR), was associated with hypertriglyceridemia in adults. Because accumulation of triglycerides in hepatocytes represents the hallmark of steatosis, we aimed to investigate whether this variant might be associated with fatty liver (hepatic fat content, HFF%). Moreover, because recently...

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Identifiers

PMID: 22105854
DOI: 10.1002/hep.24806
PMCID: PMC3288435

Genes

GCKR
PNPLA3
APOC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents.PMID 22105854Read ↗

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