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Article

Association of glucokinase regulatory gene polymorphisms with risk and severity of non-alcoholic fatty liver disease: an interaction study with adiponutrin gene.

Journal of gastroenterology - 1 Jun 2014

Tan Hwa-Li, Zain Shamsul Mohd, Mohamed Rosmawati, Rampal Sanjay, Chin Kin-Fah, Basu Roma Choudhury, Cheah Phaik-Leng, Mahadeva Sanjiv, Mohamed Zahurin

Abstract excerpt

BACKGROUND: Recent genome-wide association studies demonstrated an association between single nucleotide polymorphisms (SNPs) on the glucokinase regulatory gene (GCKR) with hepatic steatosis. This study attempted to investigate the association of GCKR rs780094 and rs1260326 with susceptibility to non-alcoholic fatty liver disease (NAFLD) and its severity. METHODS: The genotypes were assessed on 144 histologically...

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Source

Identifiers

PMID: 23800943
DOI: 10.1007/s00535-013-0850-x

Genes

GCKR
PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of glucokinase regulatory gene polymorphisms with risk and severity of non-alcoholic fatty liver disease: an interaction study with adiponutrin gene.PMID 23800943Read ↗

Common variant in the glucokinase regulatory gene rs780094 and risk of nonalcoholic fatty liver disease: a meta-analysis.Semantic proximity Read ↗

Contribution of Rs780094 and Rs1260326 Polymorphisms in GCKR Gene to Non-alcoholic Fatty Liver Disease: A Meta-Analysis Involving 26,552 Participants.Semantic proximity Read ↗

Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic fatty liver disease.Semantic proximity Read ↗

Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people.Semantic proximity Read ↗

Association of rs780094 polymorphism of glucokinase regulatory protein with non-alcoholic fatty liver disease.Semantic proximity Read ↗

Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents.Semantic proximity Read ↗

Prevalence of GCKR rs1260326 Variant in Subjects with Obesity Associated NAFLD and T2DM: A Case-Control Study in South Punjab, Pakistan.Semantic proximity Read ↗

GCKR polymorphism influences liver fat content in patients with type 2 diabetes.Semantic proximity Read ↗

A Rare Nonsense Mutation in the Glucokinase Regulator Gene Is Associated With a Rapidly Progressive Clinical Form of Nonalcoholic SteatohepatitisSemantic proximity Read ↗

A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease.Semantic proximity Read ↗

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity.Semantic proximity Read ↗

Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study.Semantic proximity Read ↗

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