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Article

14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes.

Diabetes research and clinical practice - 1 Dec 2022

Gjesing Anette P, Engelbrechtsen Line, Cathrine B Thuesen Anne, Have Christian T, Hollensted Mette, Grarup Niels, Linneberg Allan, Steen Nielsen Jens, Christensen Lotte B, Thomsen Reimar W, Johansson Kristoffer E, Cagiada Matteo, Gersing Sarah, Hartmann-Petersen Rasmus, Lindorff-Larsen Kresten, Vaag Allan, Sørensen Henrik T, Brandslund Ivan, Beck-Nielsen Henning, Pedersen Oluf, Rungby Jørgen, Hansen Torben

Abstract excerpt

AIMS: Rare variants in the glucokinase gene (GCK) cause Maturity-Onset Diabetes of the Young (MODY2/GCK-MODY). We investigated the prevalence of GCK variants, phenotypic characteristics, micro- and macrovascular disease at baseline and follow-up, and treatment among individuals with and without pathogenic GCK variants. METHODS: This is a cross-sectional study in a population-based cohort of 5,433 individuals...

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Identifiers

PMID: 36400171
DOI: 10.1016/j.diabres.2022.110159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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