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Estrogen Signals Through Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease.

Gastroenterology - 1 Jan 2017

Besse-Patin Aurèle, Léveillé Mélissa, Oropeza Daniel, Nguyen Bich N, Prat Annik, Estall Jennifer L

Abstract excerpt

BACKGROUND & AIMS: Inefficient fatty acid oxidation in mitochondria and increased oxidative damage are features of non-alcoholic fatty liver disease (NAFLD). In rodent models and patients with NAFLD, hepatic expression of peroxisome proliferator-activated receptor-γ (PPARG) coactivator 1α (PPARGC1A or PGC1A) is inversely correlated with liver fat and disease severity. A common polymorphism in this gene...

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Identifiers

PMID: 27658772
DOI: 10.1053/j.gastro.2016.09.017

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PPARG

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