Article
Gly482Ser mutation impairs the effects of peroxisome proliferator-activated receptor γ coactivator-1α on decreasing fat deposition and stimulating phosphoenolpyruvate carboxykinase expression in hepatocytes.
Nutrition research (New York, N.Y.) - 1 Apr 2013
Chen Yanming, Mu Panwei, He Shengqing, Tang Xixiang, Guo Xin, Li Honggui, Xu Hang, Woo Shih-Lung, Qian Xiaoxian, Zeng Longyi, Wu Chaodong
Abstract excerpt
Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is a transcriptional coactivator of nuclear receptor peroxisome proliferator-activated receptor γ that critically regulates glucose and fat metabolism. Although clinical evidence suggests that Gly482Ser polymorphism of PGC-1α is associated with an increased incidence of nonalcoholic fatty liver disease, a direct role for Gly482Ser mutation in...
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