Downregulation of the MARC1 p.A165 risk allele reduces hepatocyte lipid content by increasing beta-oxidation.

doi:10.3350/cmh.2024.0642

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Downregulation of the MARC1 p.A165 risk allele reduces hepatocyte lipid content by increasing beta-oxidation.

Clinical and molecular hepatology - 1 Apr 2025

Ciociola Ester, Dutta Tanmoy, Sasidharan Kavitha, Kovooru Lohitesh, Noto Francesca R, Pennisi Grazia, Petta Salvatore, Mirarchi Angela, Maurotti Samantha, Scopacasa Bernardette, Tirinato Luca, Candeloro Patrizio, Henricsson Marcus, Lindén Daniel, Jamialahmadi Oveis, Pujia Arturo, Mancina Rosellina M, Romeo Stefano

Abstract excerpt

BACKGROUND/AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global epidemic. The disease has a strong genetic component, and a common missense variant (rs2642438) in the mitochondrial amidoxime-reducing component 1 (MARC1) gene confers protection against its onset and severity. However, there are contrasting results regarding the mechanisms that promote this protection. METHODS: We...

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PMID: 39716370
DOI: 10.3350/cmh.2024.0642
PMCID: PMC12016604

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