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Article

Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice.

The American journal of pathology - 1 Aug 2011

Huang Jiansheng, Viswakarma Navin, Yu Songtao, Jia Yuzhi, Bai Liang, Vluggens Aurore, Cherkaoui-Malki Mustapha, Khan Mushfiquddin, Singh Inderjit, Yang Gongshe, Rao M Sambasiva, Borensztajn Jayme, Reddy Janardan K

Abstract excerpt

Fatty acyl-coenzyme A oxidase 1 (ACOX1) knockout (ACOX1(-/-)) mice manifest hepatic metabolic derangements that lead to the development of steatohepatitis, hepatocellular regeneration, spontaneous peroxisome proliferation, and hepatocellular carcinomas. Deficiency of ACOX1 results in unmetabolized substrates of this enzyme that function as biological ligands for peroxisome proliferator-activated receptor-α...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21801867
DOI: 10.1016/j.ajpath.2011.04.030
PMCID: PMC3157234

Genes

ACOX1

Provenance

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