Sex Dimorphism of Nonalcoholic Fatty Liver Disease (NAFLD) in Pparg-Null Mice.

doi:10.3390/ijms22189969

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Article

Sex Dimorphism of Nonalcoholic Fatty Liver Disease (NAFLD) in Pparg-Null Mice.

International journal of molecular sciences - 15 Sept 2021

Schiffrin Mariano, Winkler Carine, Quignodon Laure, Naldi Aurélien, Trötzmüller Martin, Köfeler Harald, Henry Hugues, Parini Paolo, Desvergne Béatrice, Gilardi Federica

Abstract excerpt

Men with nonalcoholic fatty liver disease (NAFLD) are more exposed to nonalcoholic steatohepatitis (NASH) and liver fibrosis than women. However, the underlying molecular mechanisms of NALFD sex dimorphism are unclear. We combined gene expression, histological and lipidomic analyses to systematically compare male and female liver steatosis. We characterized hepatosteatosis in three independent mouse models of...

Topics

Animals
Disease Models, Animal
Fatty Acids
Female
Gene Expression Regulation
Gonadal Steroid Hormones
Inflammation
Lipid Droplets
Liver
Male
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Knockout

Non-alcoholic Fatty Liver Disease

PPAR gamma

Phenotype

Sex Characteristics

Signal Transduction

Triglycerides

Source

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Identifiers

PMID: 34576136
DOI: 10.3390/ijms22189969
PMCID: PMC8467431

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