Article
ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy.
EMBO reports - 1 May 2014
Wu Wenxian, Tian Weili, Hu Zhe, Chen Guo, Huang Lei, Li Wen, Zhang Xingli, Xue Peng, Zhou Changqian, Liu Lei, Zhu Yushan, Zhang Xingliang, Li Longxuan, Zhang Liangqing, Sui Senfang, Zhao Bin, Feng Du
Abstract excerpt
Autophagy eliminates dysfunctional mitochondria in an intricate process known as mitophagy. ULK1 is critical for the induction of autophagy, but its substrate(s) and mechanism of action in mitophagy remain unclear. Here, we show that ULK1 is upregulated and translocates to fragmented mitochondria...
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