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Article

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells.

Nature cell biology - 22 Jan 2012

Liu Lei, Feng Du, Chen Guo, Chen Ming, Zheng Qiaoxia, Song Pingping, Ma Qi, Zhu Chongzhuo, Wang Rui, Qi Wanjun, Huang Lei, Xue Peng, Li Baowei, Wang Xiaohui, Jin Haijing, Wang Jun, Yang Fuquan, Liu Pingsheng, Zhu Yushan, Sui Senfang, Chen Quan

Abstract excerpt

Accumulating evidence has shown that dysfunctional mitochondria can be selectively removed by mitophagy. Dysregulation of mitophagy is implicated in the development of neurodegenerative disease and metabolic disorders. How individual mitochondria are recognized for removal and how this process is regulated remain poorly understood. Here we report that FUNDC1, an integral mitochondrial outer-membrane protein, is a...

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Source

Identifiers

PMID: 22267086
DOI: 10.1038/ncb2422

Genes

FUNDC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells.PMID 22267086Read ↗

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