Article
Structural basis of target recognition by Atg8/LC3 during selective autophagy.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2008
Noda Nobuo N, Kumeta Hiroyuki, Nakatogawa Hitoshi, Satoo Kenji, Adachi Wakana, Ishii Junko, Fujioka Yuko, Ohsumi Yoshinori, Inagaki Fuyuhiko
Abstract excerpt
Autophagy is a non-selective bulk degradation process in which isolation membranes enclose a portion of cytoplasm to form double-membrane vesicles, called autophagosomes, and deliver their inner constituents to the lytic compartments. Recent studies have also shed light on another mode of autophagy that selectively degrades various targets. Yeast Atg8 and its mammalian homologue LC3 are ubiquitin-like modifiers...
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