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Article

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

2 Apr 2016

Abstract excerpt

Mitochondrial fragmentation due to imbalanced fission and fusion of mitochondria is a prerequisite for mitophagy, however, the exact "coupling" of mitochondrial dynamics and mitophagy remains unclear. We have previously identified that FUNDC1 recruits MAP1LC3B/LC3B (LC3) through its LC3-interacting region (LIR) motif to initiate mitophagy in mammalian cells. Here, we show that FUNDC1 interacts with both...

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Identifiers

PMID: 27050458
DOI: 10.1080/15548627.2016.1151580

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