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Article

G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance.

Endocrinology - 1 Nov 2016

Boortz Kayla A, Syring Kristen E, Lee Rebecca A, Dai Chunhua, Oeser James K, McGuinness Owen P, Wang Jen-Chywan, O'Brien Richard M

Abstract excerpt

The glucose-6-phosphatase catalytic subunit 2 (G6PC2) gene encodes an islet-specific glucose-6-phosphatase catalytic subunit. G6PC2 forms a substrate cycle with glucokinase that determines the glucose sensitivity of insulin secretion. Consequently, deletion of G6pc2 lowers fasting blood glucose (FBG) without affecting fasting plasma insulin. Although chronic elevation of FBG is detrimental to health,...

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Identifiers

PMID: 27653037
DOI: 10.1210/en.2016-1678
PMCID: PMC5086534

Genes

FOXA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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