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Article

Global deformation facilitates flipping of damaged 8-oxo-guanine and guanine in DNA.

Nucleic acids research - 16 Nov 2016

La Rosa Giuseppe, Zacharias Martin

Abstract excerpt

Oxidation of guanine (Gua) to form 7,8-dihydro-8-oxoguanine (8oxoG) is a frequent mutagenic DNA lesion. DNA repair glycosylases such as the bacterial MutM can effciently recognize and eliminate the 8oxoG damage by base excision. The base excision requires a 8oxoG looping out (flipping) from an intrahelical base paired to an extrahelical state where the damaged base is in the enzyme active site. It is still...

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Identifiers

PMID: 27651459
DOI: 10.1093/nar/gkw827
PMCID: PMC5175360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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