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Article

Critical role of DNA intercalation in enzyme-catalyzed nucleotide flipping.

Nucleic acids research - 10 Nov 2014

Hendershot Jenna M, O'Brien Patrick J

Abstract excerpt

Nucleotide flipping is a common feature of DNA-modifying enzymes that allows access to target sites within duplex DNA. Structural studies have identified many intercalating amino acid side chains in a wide variety of enzymes, but the functional contribution of these intercalating residues is poorly understood. We used site-directed mutagenesis and transient kinetic approaches to dissect the energetic contribution...

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PMID: 25324304
DOI: 10.1093/nar/gku919
PMCID: PMC4227769

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