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Article

The impact of abasic sites on DNA flexibility.

Journal of biomolecular structure & dynamics - 1 Feb 2000

Ayadi L, Coulombeau C, Lavery R

Abstract excerpt

We use internal coordinate molecular mechanics calculations to study the impact of abasic sites on the conformation and the mechanics of the DNA double helix. Abasic sites, which are common mutagenic lesions, are shown to locally modify both the groove geometry and the curvature of DNA in a sequence dependent manner. By controlled twisting and bending, it is also shown that these lesions modify the deformability...

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Identifiers

PMID: 10698102
DOI: 10.1080/07391102.2000.10506555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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