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Efficacy and safety of low levels of low-density lipoprotein cholesterol: trans-ancestry linear and non-linear Mendelian randomization analyses

11 Apr 2023

Abstract excerpt

AIMS: LDL cholesterol (LDL-C) is a well-established risk factor for coronary artery disease (CAD). However, the optimal LDL-C level with regard to efficacy and safety remains unclear. We aimed to investigate the causal relationships between LDL-C and efficacy and safety outcomes. METHODS AND RESULTS: We analyzed 353 232 British from the UK Biobank and 41 271 Chinese from the China-PAR project. Linear and...

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Diabetes, Cardiovascular Risks, and Lipoproteins
Genetic Associations and Epidemiology
Lipoproteins and Cardiovascular Health

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37040432
DOI: 10.1093/eurjpc/zwad111

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