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Article

Interaction between childhood adversity and functional polymorphisms in the dopamine pathway on first-episode psychosis.

Schizophrenia research - 1 Mar 2019

Trotta Antonella, Iyegbe Conrad, Yiend Jenny, Dazzan Paola, David Anthony S, Pariante Carmine, Mondelli Valeria, Colizzi Marco, Murray Robin M, Di Forti Marta, Fisher Helen L

Abstract excerpt

BACKGROUND: There is consistent evidence of a cumulative relationship between childhood adversity and psychosis, with number of adversities experienced increasing the probability of psychosis onset. It is possible that genetic factors moderate the association between childhood adversity and psychosis, potentially by influencing how an individual reacts biologically and/or psychologically following exposure to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29653893
DOI: 10.1016/j.schres.2018.04.010

Genes

AKT1
COMT
DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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