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Article

Childhood maltreatment mediates the effect of the genetic background on psychosis risk in young adults.

Translational psychiatry - 1 Jun 2022

Marchi Mattia, Elkrief Laurent, Alkema Anne, van Gastel Willemijn, Schubart Chris D, van Eijk Kristel R, Luykx Jurjen J, Branje Susan, Mastrotheodoros Stefanos, Galeazzi Gian M, van Os Jim, Cecil Charlotte A, Conrod Patricia J, Boks Marco P

Abstract excerpt

Childhood maltreatment (CM) and genetic vulnerability are both risk factors for psychosis, but the relations between them are not fully understood. Guided by the recent identification of genetic risk to CM, this study investigates the hypothesis that genetic risk to schizophrenia also increases the risk of CM and thus impacts psychosis risk. The relationship between schizophrenia polygenetic risk, CM, and...

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Source

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Identifiers

PMID: 35650188
DOI: 10.1038/s41398-022-01975-1
PMCID: PMC9160238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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