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Article

CRISPR-based knockout and base editing confirm the role of MYRF in heart development and congenital heart disease.

Disease models & mechanisms - 1 Aug 2023

Doering Lino, Cornean Alex, Thumberger Thomas, Benjaminsen Joergen, Wittbrodt Beate, Kellner Tanja, Hammouda Omar T, Gorenflo Matthias, Wittbrodt Joachim, Gierten Jakob

Abstract excerpt

High-throughput DNA sequencing studies increasingly associate DNA variants with congenital heart disease (CHD). However, functional modeling is a crucial prerequisite for translating genomic data into clinical care. We used CRISPR-Cas9-mediated targeting of 12 candidate genes in the vertebrate model medaka (Oryzias latipes), five of which displayed a novel cardiovascular phenotype spectrum in F0 (crispants):...

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Identifiers

PMID: 37584388
DOI: 10.1242/dmm.049811
PMCID: PMC10445736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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