Article

Early Subclinical and Sex-Specific Cardiac Remodeling Precedes Heart Failure in Zebrafish with Human Actin T126I Mutation

2025-08-29

Abstract excerpt

<h4>Abstract/Summary</h4> Dilated cardiomyopathy (DCM) is a leading cause of heart failure with notable sex differences in disease susceptibility and progression. Mutations in sarcomeric proteins such as cardiac actin (ACTC1) contribute to familial DCM, yet the in vivo consequences of the ACTC1 p.T126I variant and its sex-specific effects remain unclear. We generated a zebrafish model carrying the orthologous Ac...

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Literature Corpus work: ee156fb5-342c-533c-aea1-1e4db9ac0072
DOI: 10.1101/2025.08.26.672352

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