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Article

Lactate regulators contribute to tumor microenvironment and predict prognosis in lung adenocarcinoma

25 Nov 2022

Abstract excerpt

Background: Lactic acid, as a product of glycolysis, increases tumor cell migration and the invasion of tumor cells in the tumor microenvironment. Besides this, lactic acid promotes the expression of programmed death-1 expression (PD-1) in regulatory T cells, which could cause the failure of PD-1 blockade therapy. However, the implications of lactic acid in the tumor microenvironment of lung adenocarcinoma (LUAD)...

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PMID: 36505423
DOI: 10.3389/fimmu.2022.1024925

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