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Article

Independent component analysis of SNPs reflects polygenic risk scores for schizophrenia.

Schizophrenia research - 1 Mar 2017

Chen Jiayu, Calhoun Vince D, Pearlson Godfrey D, Perrone-Bizzozero Nora I, Turner Jessica A, Ehrlich Stefan, Ho Beng-Choon, Liu Jingyu

Abstract excerpt

Schizophrenia is a psychiatric disorder with high heritability. Recent genome-wide association studies have provided a list of risk loci reliably derived from unprecedentedly large samples. However, further delineation of the diagnosis-associated susceptibility variants is needed to better characterize the genetic architecture given the disease's complex nature. In this sense, a data-driven approach might hold...

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Identifiers

PMID: 27637363
DOI: 10.1016/j.schres.2016.09.011
PMCID: PMC5348276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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