Article
Fine-scale genetic mapping using independent component analysis.
IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000
Dawy Zaher, Sarkis Michel, Hagenauer Joachim, Mueller Jakob C
Abstract excerpt
The aim of genetic mapping is to locate the loci responsible for specific traits such as complex diseases. These traits are normally caused by mutations at multiple loci of unknown locations and interactions. In this work, we model the biological system that relates DNA polymorphisms with complex traits as a linear mixing process. Given this model, we propose a new fine-scale genetic mapping method based on...
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