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Article

Dynamic Cell Type Specificity of SRC-1 Coactivator in Modulating Uterine Progesterone Receptor Function in Mice

31 Aug 2005

Abstract excerpt

Regulation of gene transcription by the progesterone receptor (PR) in cooperation with coactivator/corepressor complexes coordinates crucial processes in female reproduction. To investigate functional relationships between PR and steroid receptor coactivators (SRCs) in distinct cell types of uterine tissue during gene transcription, we generated a new transgenic mouse model utilizing a Progesterone Receptor...

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Share to Estrogen and related hormone effects
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PMID: 16135805
DOI: 10.1128/mcb.25.18.8150-8165.2005

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