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A possible function of Nik-related kinase in the labyrinth layer of delayed delivery mouse placentas

23 Dec 2022

Abstract excerpt

In mice and humans, Nik-related protein kinase (Nrk) is an X-linked gene that encodes a serine/threonine kinase belonging to GCK group 4. Nrk knockout (Nrk KO) mice exhibit delayed delivery, possibly due to defective communication between the Nrk KO conceptus and its mother. However, the mechanism of delayed labor remains largely unknown. Here, we found that in pregnant mothers with the Nrk KO conceptus, the...

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PMID: 36567126
DOI: 10.1262/jrd.2022-120

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