Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloalveolar development and lactation.

Oncogene - 10 Jun 1999

Jones F E, Stern D F

Abstract excerpt

Overexpression of the receptor tyrosine kinase ErbB2/HER2/Neu (ErbB2) occurs in 15-40% of human breast cancers. To determine the function of ErbB2 signaling during normal mouse mammary gland development, we expressed a carboxyl-terminal truncated dominant negative allele of ErbB2 (ErbB2deltaIC) in the developing mouse mammary gland. Despite ErbB2deltaIC expression within mammary glands of pubescent virgin and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Lactation
Share to Mammary Glands, Animal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Phosphorylation

Share to Pregnancy

Share to Receptor, ErbB-2

Source

Identifiers

PMID: 10376526
DOI: 10.1038/sj.onc.1202698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloalveolar development and lactation.PMID 10376526Read ↗

ErbB2 is required for ductal morphogenesis of the mammary glandSemantic proximity Read ↗

Insights from transgenic mouse models of ERBB2-induced breast cancer.Semantic proximity Read ↗

Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland.Semantic proximity Read ↗

ErbB2 Transgenic Mice: A Tool for Investigation of the Immune Prevention and Treatment of Mammary CarcinomasSemantic proximity Read ↗

ERBB Receptors and Their Ligands in the Developing Mammary Glands of Different Species: Fifteen Characters in Search of an AuthorSemantic proximity Read ↗

The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium.Semantic proximity Read ↗

WAP-TAg transgenic mice and the study of dysregulated cell survival, proliferation, and mutation during breast carcinogenesis.Semantic proximity Read ↗

Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice.Semantic proximity Read ↗

ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation.Semantic proximity Read ↗

Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development.Semantic proximity Read ↗

Activation of retinoblastoma protein in mammary gland leads to ductal growth suppression, precocious differentiation, and adenocarcinoma.Semantic proximity Read ↗

The breast proto-oncogene, HRGα regulates epithelial proliferation and lobuloalveolar development in the mouse mammary glandSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.